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DallAngelo A, Mandrini S, Sala V et al (2014) Platysma synkinesis in facial palsy and botulinum toxin type A

For adults, the daily recommended intake of Vitamin B12 is 1.5 micrograms per day and this amount is present in most balanced diets

However, due to rare but serious adverse effects (e.g., thrombocytopenia, cardiac arrhythmias, hypersensitivity reactions), many guidelines recommend against routine use

I cant tell you how many times a patient tells me they had Botox in the past and it didnt work with other physicians, nurse practitioners or physicians assistants

Side Effects & Mitigation Because there is no completed human safety trial, the honest statement is that the human side-effect profile is not well characterised

The most commonly reported side effects were mild and included headache, minor gastrointestinal disturbances (flatulence, mild diarrhea at high doses), upper respiratory symptoms, and mild injection site reactions