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CGI-E takes into account both the therapeutic effect and adverse events, ranging from 1 (marked therapeutic effect) to 04 (unchanged or worse)

Mechanistic studies showed that EGCG activated PI3K/Akt pro-survival signaling and suppressed the MAPK pathway, thereby reducing neuroinflammation and neuronal apoptosis

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Lifelong Voluntary Exercise Modulates Age-Related Changes in Oxidative Stress