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Bolmers MD, Bom WJ, Scheijmans JCG, et al

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radiotherapy [RT] or brachytherapy) can be associated with ED [302,304,305]

Chronic brain injury may occur in a region of iron deposition and is associated with tissue loss

Most patients notice initial metabolic shifts such as changes in energy or early body composition feedback within two to four weeks

Thus, reduced modification of both HDL and LDL by reactive dicarbonyls, including MDA and IsoLG, likely contribute to the antiatherogenic properties of 2-HOBA (Figure 6)
