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In addition to being synthesized by cardiomyocytes and known to modulate vascular permeability and dilation/constriction, NPPC is also produced locally by Sertoli cells in the testis and serves in an autocrine manner (80)

Janaky R, et al

GSH is primarily synthesized in liver, and decreased levels of circulating GSH have been reported in liver diseases, including metabolic dysfunctionassociated steatotic liver disease (MASLD) and metabolic dysfunctionassociated steatohepatitis (MASH) (4, 5)