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evaluated intraduodenal (ID) infusions of glutamine (7.5 or 15 g) or saline over 30 min in healthy subjects and 15 g glutamine or saline in T2DM patients followed by an ID infusion of glucose over 100 min [36]

This gradual decrease in vitamin B6 and the development of seizures is a major cause of peripheral neuropathy

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Therefore, the expression of ALS and IGFBP-3 in non-hepatic tissues and possible IGF-I-independent effects of IGFBP-3, should be considered when analyzing findings