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How AOD-9604 Works at the Cellular Level AOD-9604 exerts its fat-reducing effects through activation of beta-3 adrenergic receptors located predominantly in adipose (fat) tissue

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It establishes a robust yet adaptable coordination with Cu(II) ions, utilizing the amino group of glycine, the imidazole nitrogen of histidine, and the -amino group of lysine

Additionally, results from cycloheximide pulse-chase assay showed that YAP1 protein was less stable in cells depleting CDK4/6 or treated with Abemaciclib (Figs