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The less diverse cell death signaling network in erythrocytes is associated primarily with expulsion of their organelles during maturation and makes Ca 2+ signaling a master regulator of eryptosis, while the caspase-dependent apoptotic machinery is more sophisticated and redundant

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PRL levels within the physiological or metabolic range can promote -cell proliferation and survival, improve insulin sensitivity, inhibit gluconeogenesis, optimize lipid distribution, and reduce the risk of fatty liver disease ( 7 Clinical implications and future directions 7.1 Therapeutic considerations in patients with obesity and hyperprolactinemia Currently, weight management strategies are divided into three categories: lifestyle interventions, drug therapy, and metabolic/bariatric surgeries