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The AGE-RAGE system may be responsible for the failure of ovulation characteristic of PCOS: in a model of human cell lines of granulosa, observed that the AGE interfere in vitro with the action of LH leading to altered follicular development and therefore the dysfunction ovulatory associated with PCOS [65]

Testa I, Salvatori C, Di Cara G, Latini A, Frati F, Troiani S et al (2018) Soy-Based Infant Formula: Are Phyto-Oestrogens Still in Doubt