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1) through a series of enzymatic reactions involving metabolites such as 5-hydroxytryptophan, serotonin, and N-acetylserotonin [23]

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By contrast, priming refers to the transformation of PMNs following exposure to a ligand that does not itself induce superoxide production, but does render the PMNs more amenable to robust activation of NADPH oxidase upon binding to a second ligand (El-Benna et al., 2008, 2016)

Importantly, Nrf2 regulates transcription of the rate-limiting enzyme responsible for synthesizing GSH, -glutamate-cysteine ligase (Yang et al., 2005)