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Superoxide radical and hydroperoxyl radical An important electron transfer reaction occurs in mitochondria via leakage of an electron from the electron transfer chain to oxygen during oxidative phosphorylation, resulting in the formation of a primary radical, superoxide radical anion (O 2 + e O 2 ) (Boveris and Cadenas 1982)

Redox Biol (2019) 23:101107

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[DOI] [PubMed] [Google Scholar] 4.O'Rourke B, Ramza BM, Marban E

In preclinical models of this disease, neuroinflammatory markers like microglia and astroglia reactivity have been observed, yielding interesting results and showing decreases in neuroinflammatory biomarkers after MEM treatments

The accumulation of senescent cells during aging leads to chronic inflammation, which contributes to organ and tissue decline