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This section summarizes current research progress on mitochondrial biogenesis, mitophagy, and mitochondrial dynamics in common neurodegenerative diseases (AD, PD, HD, and ALS) (Figure 5)

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Disease onset usually occurs in young adults, more common in females and has a prevalence ranging between 2 and 150 per 100,000.[1] The prevalence of MS in Isfahan-Iran is 43.8 per 100,000.[2] The etiology of MS is complex and multi-factorial involving both genetic and environmental factors, but the main etiology is still unknown.[1] Vitamin B 12 , also known as Cobalamin, plays important structural and functional roles in nervous system and its deficiency leads to demyelination, followed by axonal degeneration and eventually irreversible damage due to axonal death