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Some compounded tirzepatide formulations include B12 (methylcobalamin), and researchers report improved energy levels with this addition

Folic acid is contraindicated for use in patients with folic acid hypersensitivity

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Folic acid (5mg weekly) should be given with methotrexate to reduce risk of gastrointestinal and liver toxicity[1]

Vitamin B-12 Is required for the development and function of the central nervous system Is necessary for the formation of red blood cells and DNA Is involved in the breakdown of a protein called homocysteine, which is associated with an increased risk of heart disease and stroke Helps maintain healthy nerve cells and is involved in the production of DNA and RNA Works closely with vitamin B9 (folate or folic acid) to help make red blood cells and to help iron work better in the body Aids in the production of S-adenosylmethionine (SAMe), a compound involved in immune function and mood Vitamin B-12 deficiency is relatively common, and studies show that in the United States, approximately 6% of adults under 60 have a vitamin B12 deficiency, and close to 20% of those older than 60

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