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The activation of the Na + /H + exchanger (NHE), as an attempt to correct acidosis, leads to an accumulation of intracellular Na + , which in turn inhibits Ca 2+ extrusion through the Na + /Ca 2+ exchanger (NCX), thereby contributing to calcium overload [163]

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As GLP-1 medications improve blood glucose control, this osmotic diuresis resolves, which may paradoxically feel like a change in urinary pattern to patients accustomed to frequent urination

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2026 Prohibited List Category S2, Peptide Hormones, Growth Factors, Related Substances and Mimetics

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