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Quantification of BBB dysfunction was calculated as described previously 70,72

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Protocol overview: BPC-157 administered via subcutaneous injection, locally near the affected joint Standard dosing range: 200500 mcg per injection session Treatment duration: 48 weeks of active treatment Follow-up assessments: 6 months and 12 months post-treatment Patients were evaluated using validated pain scales (VAS and KOOS scores) and functional mobility assessments at each follow-up point

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