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Long-term dysbiosis leads to overstimulation of neuroimmune system and the hypothalamicpituitaryadrenocortical axis, along with neurotransmitter imbalance

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A.SimitsidellisI.SaundersP
1992;263:G6068

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As cell size has been linked to changes in metabolism [20, 21], we hypothesised that metabolic disturbances contribute to the increase in spontaneous cell death in ADA2 deficiency