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223 Dynamin-related protein 1 promotes fragmented mitochondrial puncta formation in latent brain metastatic cells, leading to a shift towards fatty acid oxidation (FAO) metabolism that maintains redox homeostasis and survival of tumor cells within the brain microenvironment

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Indicators of endothelial dysfunction, such as sICAM-1, tPA antigen, and PAI-1 levels and activity, are higher in individuals with Metabolic Syndrome (MetS) (67)

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Exposure to toxins, chemicals, or heavy metals may also disrupt immune tolerance

By contrast, a mixture of dKLAK-z13 and HLAH-z13 each at a low concentration showed clear cytotoxicity, but had no toxic effect on control CNGB3-negative A431 cells