benign melanotic macule Labial Labial melanotic macule (brown spot

IgG forms immune complexes with oxLDL and promotes an inflammatory macrophage phenotype while IgE also stimulates macrophages and mast cells to produce proatherogenic cytokines (95)

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The animals were maintained as national guidelines and pro- tocols, approved by the Institutional Animal Ethics Committee and in an air-conditioned animal house with constant 12 h light and 12 h dark schedule

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