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Beside generation of ROS, cyclophosphamide inhibits the endogenous antioxidant pathways, in particular nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, a master transcription factor for conserving redox homeostasis [19]

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Among them, glutathione peroxidase (GPx) stands out as it helps mitigate the harmful effects of ROS and inactivates hydrogen and lipid peroxides

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ChemBioChem 24 , e202200798 (2023)