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Funding This project was financially supported by the National Natural Science Foundation of China (92374102, 82473391, 82503859), the Science and Technology Commission of Shanghai Municipality (YDZX20243100002003, 23ZR1479300, 25ZR1402085), the Shuguang Program of Shanghai Municipal Education Commission and Shanghai Education Development Foundation (25SG10) and Noncommunicable Chronic Diseases-National Science and Technology Major Project (2024ZD0525500/2024ZD0525501/2024ZD0525505)

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