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Conclusions 7.1

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We provide original preliminary data that suggests opiorphin supplementation in semen samples from a subgroup of men with asthenozoospermia improves sperm motility parameters

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5-amino-1MQ, an analogue from our initial series of NNMT inhibitors with low IC 50 value (IC 50 = ~1 M;[17]), and high cell membrane permeability (Table 2), produced the greatest reduction of intracellular 1-MNA levels at a concentration of 10 M among tested inhibitors (Figure 2D)