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In consistent with the activated status of GCLC regulated by SIRT2, silencing of SIRT2 by shRNA or inhibitor SirReal2 in ACHN cells followed by the treatment with 700 M TBH led to a significantly compromised induction of GSH level (40% vs

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In addition, sex steroid hormones have been implicated in the modulation of genome stability in endocrine-driven malignancies, including breast and prostate cancer [138]

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Ill explain the glutathione-S-transferase genes and the impact that genetic variants have on phase II detoxification