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The underlying mechanism in most cases is oxidative stress and metabolic dysfunction that leads to the damage to the major cell structural and functional components, in particular to the proteins, lipids and the DNA, this in turn manifests as cell injury [13] [47]

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Rights and permissions Copyright information 2025 Springer Nature Switzerland AG About this chapter Cite this chapter Blecher, G., Johnson, M., Ralph, D

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doi: 10.1001/jama.2009.954

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