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An Epigenetic Perspective

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The affected enzymes, ERK1/2, along with their downstream targets, including c-Fos, c-Jun, and Egr-1, are believed to play significant roles in cell growth, migration, and angiogenesis, which is the development of new blood vessels

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The other type of MDR is based on overexpression of GSTs, which can result in direct detoxification of chemotherapeutics and/or inhibition of the MAPK signaling pathway [12]

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PMID: 38561682 35

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London: IntechOpen (2012)

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