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These observations support the notion that AD is a degenerative metabolic disease in which the impairment of glucose metabolism, mediated by reduced brain glucose uptake and lowered insulin responsiveness, is closely associated with increased OS and inflammation (392)

Manco M, Mosca A, De Peppo F, et al

10.1155/2021/2412220 57 ShiZ.ChenH.ZhouX.YangW.LinY

[DOI] [PMC free article] [PubMed] [Google Scholar] 141

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As paternal age advances, a substantial decline in reproductive cells, encompassing testicular interstitial cells, Sertoli cells, and germ cells, has been observed (Singh et al., 2003), abnormal DNA methylation patterns, the accumulation of deleterious de novo mutations, and alterations in sperm telomere length are associated with male aging (Yang et al., 2015)
