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Targeting angiopoietin to overcome resistance to anti-vascular endothelial growth factor treatment Blockade of both, VEGF and Ang2, in preclinical studies suppressed revascularization and tumor progression of cancers resistant to anti-VEGF therapy (9295)

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Notably, nonneuronal cells, including fibroblasts, endothelial cells, osteoblasts, and monocytes, also synthesize and release BDNF 4,5,6