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Despite its strong sequence similarity with the mammalian HNF4 receptors, the overall biological effects of nhr-49 on metabolism, fat storage, and life span are remarkably similar to those of the mammalian PPARs

Obesogens: a unifying theory for the global rise in obesity

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Indeed, activating mutations that map to this interface have been identified in several aPBPs as well as the structurally unrelated SEDS-bPBP enzymatic complexes from both gram-negative and gram-positive bacteria (SI Fig

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