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Konopka et al., 2020), cytoplasmic mislocalization of nuclear proteins (Neumann et al., 2006), mitochondrial dysfunction (Albers and Beal, 2000), glutamate excitotoxicity (Shaw and Ince, 1997), proteasomal and autophagic dysfunction (Chen et al., 2012), ER stress (Nagata et al., 2007

However, the most impressive results are found in the Phase 2 trials

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Interestingly, the localization of cdc20 at the centrosome is critical for its ability to regulate dendrite development