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The role of the IGF system in cancer growth and metastasis: overview and recent insights

The GSH/GSSG ratio is a widely accepted indicator of oxidative stress and cellular redox balance

speculation includes endogenous IGF-1 axis suppression or downstream insulin/glucose dynamics

1991;91(3):S6771

The main molecular targets of genistein include caspases, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), nuclear factor-B (NF-B), inhibitor of NF-B, phosphoinositide 3-kinase/Akt (PI3K/Akt), extracellular signal-regulated kinase 1/2 (ERK 1/2), mitogen-activated protein kinase (MAPK), and Wingless and integration 1/-catenin (Wnt/-catenin) signaling pathway

Collagen is essential for maintaining skin structure and firmness, and its production naturally declines with age