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And semaglutide specifically has been shown to reduce neuropathic pain in diabetic rats by inhibiting spinal neuroinflammation [8], and a 2025 review in the Korean Journal of Pain concluded that GLP-1 receptor agonists have real potential in neuropathic pain management [20]
2022;37(18):e146

"The novel glucagonagonist component introduces lessunderstood longterm safety considerations, so it is imperative that patients are followed closely by healthcare professionals experienced with this class of medicines, with cautious, stepwise use, despite the impressive efficacy," he cautioned.

This can help patients be more prepared to manage side effects should any develop during treatment

Weve seen external swelling, internal fluid shifts, headaches, stiffness, and, in rare cases, isolation of pro-growth signaling that could theoretically interact with cancer biology

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