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Young reports grants and personal fees from Allergan, grants and personal fees from Amgen, personal fees from Avanir, grants and personal fees from Alder (now Lundbeck), personal fees from Cipla, grants and personal fees from Eli Lilly, personal fees from Supernus, grants from Autonomic Technologies, grants from Colucid, grants from Cumberland, grants from Dr

Calcium overload triggers the activation of calcium-dependent enzymes, including calpains and caspases, which degrade cytoskeletal proteins and lead to neuronal death (Zhang and Bhavnani, 2006)