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[2] This combination approach, sometimes termed triple therapy (hydroquinone + retinoid + steroid), is a well-recognized strategy in melasma treatment and has been shown to produce superior outcomes compared to any of the individual components alone

Proteom 132 PrihantoA

Sarubbi FA, Wilson B, Lee M et al

An important and balanced perspective

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Findings Evidence from animal models suggests that B1R ablation or antagonism results in a healthier phenotype, characterized by improved leptin and insulin sensitivity, increased lipid oxidation, reduced adipose hypertrophy, and diminished production of proinflammatory mediators and reactive oxygen species