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To examine the extent to which the phenotypes observed were specifically caused by lower GSH levels, we rescued GSH depletion in liver-specific Gclc KO mice with GSH mono ethyl ester (GSH-ee)

Furthermore, in ecotoxicology regulatory organs recognize this issue and provide the official LD 50 thresholds for different organisms
Tao Huan for useful discussions

Notably, Acsl4 deletion in siGpx4 IECs did not protect against LPO after AA exposure (Supplementary Fig

Nat Med 2012;18:580588
Toxicology 181182:211217
