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Reported adverse reactions include paresthesia, somnolence, and decreased serum folic acid levels

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Reported adverse effects are mostly mild and transient, including injection-site reactions (pain, redness, swelling, or itching), temporary headache, nausea, dizziness or lightheadedness, increased appetite, mild fluid retention (peripheral edema), transient joint pain or stiffness, fatigue, and mild flu-like symptoms (low-grade fever, chills, myalgia)