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Contribution of small G proteins, SNARE proteins and signaling pathways to BDNF secretion Different proteins are involved in the organization of the release site, the transition of BDNF-containing vesicles from the reserve pool to a readily releasable pool, fusion pore opening, as well as disassembly of the SNARE complex

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Several synaptic adhesion genes had modified hydroxymethylation patterns following sleep deprivation, providing further evidence for the role of sleep in synaptic plasticity (Massart et al., 2014

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Subcutaneous injection produces rapid peak concentrations within 15-30 minutes followed by relatively quick clearance, potentially favoring daily administration to maintain consistent exposure in acute performance studies