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For example, ACLY is needed for the production of the eicosanoid prostaglandin E2 (PGE 2 ) in response to LPS or TNF- stimulation in phorbol-12-myristate-13-acetate (PMA)-differentiated U937 cells, human monocytic cells from histiocytoma 73

Each one includes reference dose ranges, dosing frequency, and half-life for every peptide it covers

Patients with genetic defects in STAT5b display normal size at birth, postnatal growth failure, and elevated GH

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