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Apart from -synuclein, Lewy bodies also contain many other aggregated cellular proteins, which together constitute an interactome to promote fibrillation of -synuclein ( Under normal physiological conditions -synuclein exists mostly in an N acetylated membrane bound form which results in adoption of an -helical structure (Runfola et al., 2020)

Furthermore, flavokavains A and B were shown to have immunomodulatory functions, such as the stimulation of splenocyte proliferation and the secretion of IL-2 and TNF- in harvested splenocytes, as well as an increase in the subsets of T cell populations in BALB/c mice, with flavokavain B being more potent than flavokavain A (30 g/mL) [59]

Best et al similarly reported positive effects of RT on white matter structure, demonstrating a reduced rate of white matter atrophy in individuals in the RT group compared to controls after the 1-year training intervention as well as 1 year post-intervention ( Effects of resistance exercise training on cognitive function The effects of acute and habitual exercise of any type on cognitive function are well established, with multiple quality reviews highlighting the effectiveness of resistance exercise on improved cognition across multiple domains (Landrigan et al., 2020

Carnitine is present in the form of either free carnitine (nonesterified molecule