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The second developed approach, body roundness index (BRI), associates a persons shape phenotype with high-risk adiposity components and multiple health outcomes

They present a framework to guide research and development teams based on the five most important technical determinants of project success and pipeline quality: the right target, the right patient, the right tissue, the right safety and the right commercial potential

Our findings thus reveal the source of the longevity signalling in response to germline removal, highlighting the stem cell niche as a critical signalling hub in ageing.