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SIRT1 regulates BDNF expression by deacetylating transcription factors and histones, and BDNF binding to its tyrosine kinase receptor TrkB activates FOXO, PI3K, and MAPK, affecting oxidative stress and inflammatory factor production [16,17,18,19,20]

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Nat Immunol 16(2):188 Tyrakis PA, Palazon A, Macias D, Lee KL, Phan AT, Velia P et al (2016) S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate