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This genetic mutation occurs when guanine (G) is replaced by adenine (A) at nucleotide position 1691 in the gene sequence

Role of CB2 cannabinoid receptors in the ameliorative effects of curcumin on BCG-induced depression in mice: Insights into peripheral inflammationPharmacological Research | September 2025Curcumin, the main polyphenol from the turmeric plant, shows antidepressant effects in various animal models of depression (Kulkarni et al., 2008

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Many in vitro (Reference Cruzat, Keane and Scheinpflug12) , and in vivo experiments (Reference Moura, Lollo and Morato42) , including animal models submitted to exhaustive exercise training (Reference Petry, Cruzat and Heck33,Reference Petry, Cruzat and Heck34) have identified the important role of glutamine availability/metabolism and the anti-inflammatory response mediated by HSPs

is essential to preserve blood glucose 9, 10 , we daily monitored glycemia and found that AgRP GHR KO mice exhibited lower glycemia during the initial days of F.R