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Furthermore, we provide strong evidence that CD38 deficiency or NAD supplementation markedly alleviated VSMC senescence by suppressing the biogenesis, secretion, and internalization of SA-sEVs in VSMCs, suggesting that NAD-boosting therapy and/or the application of CD38 inhibitors may be novel strategies for treating age-related diseases by suppressing VSMC senescence

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These sources help ensure the fetus receives essential nutrients for growth and development

It supports DNA repair, improves mitochondrial function, reduces cellular senescence, and enhances stem cell function