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Beyond this threshold, nasal absorption becomes increasingly unreliable due to physical limitations in transmucosal permeation

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References Hadi M, Dragovic S, van Swelm R, Herpers B, van de Water B, Russel FGM, Commandeur JNM, Groothuis GMM (2012) AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver