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If high homocysteine is due to a slower CBS enzyme, it can have the same effect on your CBS cycle as low homocysteine

Mansoor F, Kumar S, Rai P, et al

[DOI] [PubMed] [Google Scholar] 2.Karlic H., Lohninger A

The study compared PRP with several commonly used treatment modalities, including corticosteroid injections (CSI), extracorporeal shock wave therapy (ESWT), placebo, dextrose prolotherapy, phonophoresis, and meridian trigger point therapy

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The observation that oxidatively modified lipoproteins in peritoneal fluid directly induce nociception in animal models, which is suppressed by vitamin E and N-acetylcysteine, provides compelling support for antioxidant therapy in pain management [41,42,43,44]