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Another trial, SOUL (NCT03914326), has now been initiated to overcome the shortcomings of PIONEER 6 with a primary endpoint focused at proving CV superiority vs placebo

is supported by the Italian Ministry of University Research grant 20229ZA2YF

Sun, B., Jia, X., Yang, F., Ren, G

View source SURMOUNT-1 tirzepatide trial New England Journal of Medicine Peer-reviewed Phase 3 trial results for tirzepatide in adults with obesity or overweight

Its levels typically rise during fasting and fall after eating

That glucose-dependent action is why GLP-1s rarely cause hypoglycemia unless combined with insulin or sulfonylureas