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Lucas and Nichols proposed that a northward-swimming rogue shark was responsible

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When the oxidative stress state persists and the damage progresses, senescent cells enter a senescent state marked by p16 upregulation, which consequently inhibits the kinases CDK4 and CDK6, thereby maintaining the stagnant state of the cell cycle [133, 134]

Autoimmunity Autoimmunity often occurs in a setting of chronic inflammation and increased oxidative stress

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A general concept of quantitative abiotic stress sensing