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Skin Brightening : Vitamin C suppresses tyrosinase, an enzyme involved in melanin formation, helping to reduce hyperpigmentation, dark spots, and uneven skin tone

Although many of these compounds exhibit antioxidant activity in preclinical studies, they may lack robust clinical evidence to confirm their efficacy or have not been assigned an RDI by the FDA

Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease

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The ROS that are physiologically relevant include superoxide anion radicals (O 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radicals ( OH), and singlet oxygen ( 1 O 2 ), which are generally present in cells at low levels (Pizzino et al., 2017)

After treatment with different concentrations of GSH-CDs and H 2 O 2 for 24 h, the NPCs were gently washed three times with PBS