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In 2003, a large double-blind controlled clinical trial was conducted at the Department of Psychology, University of Wales-Swansea et al., UK, with an LOE of 1b

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Chemotherapy-induced peripheral neuropathy Four randomized controlled trials (RCTs) have evaluated the use of acetyl-L-carnitine (LC) for the prevention of chemotherapy-induced peripheral neuropathy (CIPN)

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