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(II) The gamma-glutamylcysteine synthetase enzyme is the main rate-limiting step in this cycle, and this reaction is non-allosterically inhibited by physiologic concentrations of glutathione

Subcutaneous injection bypasses first-pass hepatic metabolism, delivering more active peptide to target tissues

Unhealthy brains consistently have lower glutathione and higher markers of oxidative stress

Immunobiology 216, 322333

For example, either oxidative stress or changes in intracellular Ca 2+ levels enhance the translocation of S100A2 from the nucleus to the cytoplasm

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