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In pernicious anaemia, the immune system mistakenly attacks the gastric parietal cells that produce intrinsic factor, leading to B12 deficiency over time

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doi: 10.3389/fphar.2019.01102 Received 07 May 2019 Accepted 26 August 2019 Published 20 September 2019 Volume 10 - 2019 Edited by Deslypere Jean Paul, Besins Healthcare, Thailand Reviewed by Pooja Dhupkar, University of Texas MD Anderson Cancer Center, United States

However, at the same time that folate deficiency was largely eliminated in these populations, the prevalence of intake exceeding the Tolerable Upper Intake Level of folic acid intake (1 mg/d) increased substantially (6, 22), although this was attributed to the concurrent use of supplements and fortified ready-to-eat cereals rather than to fortification alone