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First you will see a report from 1971 that in a study on excessive prescribing, B12 treatment was singled out, possibly due to the idea that GPs were giving patients B12 injections, willy nilly as a tonic

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Clusters of macrophage, T cell, alveolar cell and fibroblast were re-clustered with the same strategy
Although further study of these interactions is necessary, patients receiving these agents concurrently should be monitored for the desired therapeutic response to vitamin B12

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Disorders of purine and pyrimidine metabolism