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Additionally, baicalin can trigger autophagy in HCC cells and upregulate CD147 expression, which increases Beclin one expression through the activation of the PI3K/AKT pathway (Zhang et al., 2012a

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Right panel : The corresponding site in hSERT

Hseu YC, Vudhya Gowrisankar Y, Chen XZ, Yang YC, Yang HL

14 709721 Sabharwal SS, Waypa GB, Marks JD and Schumacker PT 2013 Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling

As we discussed earlier, MTHFR function is essential for catalyzing the conversion of folic acid to the biologically active form, methylfolate